Study on the predictions of gene function and protein structure using multi-SVM and hybrid EDA

制度:新 ; 報告番号:甲3199号 ; 学位の種類:博士(工学) ; 授与年月日:2011/3/15 ; 早大学位記番号:新549

Inelastic, Exchange, and Reactive Processes in Rovibrationally Excited Collisions of HD With H

The HD molecule is an important coolant in early universe chemistry models and a tracer of H2 in star-forming regions. Rate coefficients for collisional excitation and de-excitation of HD rotational and vibrational levels form important ingredients in astrophysical models. While collisions with He, H2, and H are the most important, available data for H + HD collisions are largely limited to temperatures less than 1000 K for the vibrational ground state, low-lying rotational levels of the v = 1 HD vibrational level, or computed without reactive contributions. Here, through explicit quantum scattering calculations, we report extensive data for rovibrational transitions in HD induced by H atoms for a range of rotational levels in v = 1 and some v = 0 levels for temperatures up to 1000 K. The significance of the computed results for astrophysical modeling is discussed

Association between prothrombin time-international normalized ratio and prognosis of post-cardiac arrest patients: A retrospective cohort study

BackgroundCardiac arrest (CA) can activate blood coagulation. This study aimed to explore the potential prognostic value of prothrombin time–international normalized ratio (INR) in post-CA patients.MethodsThe clinical data of eligible subjects diagnosed with CA was extracted from the MIMIC-IV database as the training cohort. Restricted cubic spline (RCS), Kaplan–Meier (K-M) survival curve, and Cox regression analyses were conducted to elucidate the association between the INR and all-cause mortality of post-CA patients. Subgroup analysis, propensity score matching (PSM), and inverse probability of treatment (IPTW) were also conducted to improve stability and reliability. Data of the validation cohort were collected from the eICU database, and logistic-regression analyses were performed to verify the findings of the training cohort.ResultsA total of 1,324 subjects were included in the training cohort. A linear correlation existed between INR and the risk of all-cause death of post-CA patients, as shown in RCS analysis, with a hazard ratio (HR) >1 when INR exceeded 1.2. K-M survival curve preliminarily indicated that subjects with INR ≥ 1.2 presented lower survival rate and shorter survival time, and the high level of INR was independently associated with 30-day, 90-day, 1-year, and in-hospital mortalities, with multivariate-adjusted HR of 1.44 (1.20, 1.73), 1.46 (1.23, 1.74), 1.44 (1.23, 1.69), and 1.37 (1.14, 1.64), respectively. These findings were consistent and robust across the subgroup analysis, PSM and IPTW analyses, and validation cohort.ConclusionsWe systematically and comprehensively demonstrated that elevated INR was associated with increased short- and long-term all-cause mortality of post-CA patients. Therefore, elevated INR may be a promising biomarker with prognosis significance

Microstructure and electrical properties in three-component (Al2O3–TiO2)/polyimide nanocomposite films

Polyimide (PI)-matrix composite films containing inorganic nanoparticles (nano-Al2O3 and nano-TiO2) have been fabricated. A proposed model is used to explain different structures of the (Al2O3–TiO2)/PI (ATP) films synthesized by employing in situ polymerization. Dependences of dielectric permittivities of the ATP films on frequency and temperature were studied. Results show the breakdown strength of the films decreases with prolonging the corona aging time. The incorporation of the nano-Al2O3 and nano-TiO2 particles significantly improves the corona resistance of the films. The corona aging also influences the infrared absorbance, the glass transition temperature (Tg), and loss factor (tand) of the ATP films

Comparison on Efficacy of S-1 Respectively Combined with Oxaliplatin and Docetaxel for Advanced Gastric Cancer

Objective: To compare the short-term efficacy and safety of S-1 respectively combined with oxaliplatin (OXA) and docetaxel (TXT) in treatment of advanced gastric cancer. Method: Forty-three patients with advanced gastric cancer were randomly divided into OXA group (n ＝ 26) and TXT group (n ＝ 17). Drug usage was as follows: oral administration of 40 mg/m2 S-1 during days 1 - 14, twice a day; intravenous injection of 130 mg/m2 OXA on day 1; intravenous injection of 60 mg/m2 TXT on day 1; 3 weeks as one cycle. The efficacy, adverse reactions and quality of life were evaluated 2 cycles after treatment. Results: Adverse reactions could be evaluated in all cases, and efficacy be evaluated in 42 cases. The response rates (RR) were 57.7% and 31.3% respectively in OXA and TXT groups, without statistical significance (P ＝ 0.096). The incidence of total leukopenia (100.0%), stomatitis (35.3%) and constipation (76.5%) was obviously higher in TXT group than in OXA group (50.0%, 3.8%, 38.4%), with statistical significance (P ＝ 0.019, 0.006, 0.015), while that of neurotoxicity lower than in OXA group (53.8% vs. 17.6%), with statistical significance (P ＝ 0.018). Conclusion: For advanced gastric cancer, S-1 combined with OXA is similar to efficacy of combined with TXT, but with less adverse reactions